Contemporary changes of socio-economic development factors. The aim of the work is to determine the scope of contemporary changes of socio-economic development factors, paying attention to the consequences for their interpretation and mechanism of impact relating to the regional and local level. The main goal is specified by formulating the following research questions: (1) What major megatrends shape contemporary developmental transformations? (2) What is the direction and scope of changes in socio-economic development factors? (3) How are the conditions of development processes changing as a result of these changes and how they differentiate the processes of development in space? The article is a synthesis of the results of two research projects of the National Science Center: NN 306 79 19 40: Socio-economic development and the development of areas of growth and areas of economic stagnation (2011–2014) and OPUS 10 – 2015/19/B/HS5/00012: New challenges of regional policy in shaping the factors of socio-economic development of less developed regions (2016–2019) and the results of own authors’ research – employees of the Regional Analysis Department at the Institute of Socio-Economic Geography and Spatial Management of the Adam Mickiewicz University in Poznań.