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Abstract

The purpose of the studies was to estimate efficiency of delivering nebulised drugs into the lower respiratory tract through endotracheal tubes (ET tubes) which are commonly used in the treatment of uncooperative patients. Water solution of Disodium Cromoglycate (DSCG) was nebulised with a constant air flow (25 l/min). Experimental studies were done for eight ET tubes with varying sizes (internal diameter, length) and made of two different materials. Size distribution of aerosol leaving ET tubes was determined with the use of aerosol spectrometer. Fine Particle Fraction (FPF) and Mass Median Aerodynamic Diameter (MMAD) were calculated for the aerosol leaving each tube. Additionally, mass of the Disodium Cromoglycate deposited into each endotracheal tube was determined. ET tubes can significantly influence the parameters of delivered aerosol depending on their diameter. FPF of aerosol delivered in to the respiratory tract is lower if small endotracheal tubes are used. However, MMAD and FPF for large endotracheal tubes are almost identical with MMAD and FPF from nebuliser. The results indicate that a substantial fraction of large droplets is eliminated from the aerosol stream in long endotracheal tubes (270 mm). In this case the mass of drug delivered through ET tubes is reduced but the content of small droplets increases (high value of FPF).
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Abstract

This study attempted to manufacture an Y2O3 ceramic coating layer on a ceramic (AlN) substrate using aerosol deposition (AD) and investigated its macroscopic properties. Pure Y2O3 powder with a polygonal shape and average size of 5.0 μm was used as initial feedstock. Using aerosol deposition with suitable process conditions, an Y2O3 coating layer was successfully fabricated on aluminum nitride (AIN). The thickness of the manufactured coating layer was approximately 10 mm. The coating layer consisted of Y2O3 phase identical to that in the initial powder, and no additional oxides were identified. In regard to the roughness of the Y2O3 coating layer, the average roughness (Ra) measured 1.32 μm, indicating that the surface roughness was relatively even compared to the initial powder size (5 μm). Mechanical properties of the Y2O3 coating layer were measured using nano indentation equipment, and the indentation modulus of the Y2O3 coating layer fabricated by aerosol deposition measured 136.5 GPa. The interface of the coating layer was observed using TEM, and the deposition mechanism of the Y2O3 coating layer manufactured by aerosol deposition was also discussed.
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