The aim of this study was to investigate interactions between conventional antifungal drug and essential oils against isolates of Malassezia pachydermatis. Antifungal activity of Cinnamomum cassia, Melaleuca alternifolia, Mentha piperita, Origanum vulgare and Syzygium aromaticum essential oils were tested against 19 strains of M. pachydermatis isolated from healthy dogs and reference strain M. pachydermatis CBS 1879. The checkerboard assay was used to search for in- teractions. Synergism was observed for the combination of clotrimazole with Melaleuca alternifolia essential oil, Mentha piperita and Origanum vulgare. The combinations of Cinnamomum cassia and Syzygium aromaticum essential oils with clotrimazole showed indifferent effect. Additive antimicrobial activity was observed for the combination of clotrimazole with Syzygium aromaticum and Melaleuca alternifolia essential oils against reference strain. The obtained results showed synergistic interactions between essential oils and clotrimazole which could improve effectiveness of this antifungal drug.
The aim of the article is to discuss the written legacy of Philaret Drozdov, the Orthodox Metropolitan of Moscow (lived 1782–1867), in the context of human freedom and the freedom of the imperial Russia’s system – the autocracy. The basic research material constitutes of four homilies by Philaret Drozdov written in the years 1849–1856. To present a certain evolution of the Russian thought the author of the article also cites works which were created in earlier periods, i.e.: in the Moscow Russia time and in the time of Peter I. First, the author presents the orthodox anthropology as the ideological base for Philaret Drozdov’s considerations of freedom and power. Then, individual texts are discussed in detail in order to define the view of the Metropolitan of Moscow on the foregoing issues. At the end, the author sums up the carried out analysis and presents conclusions.