Single-frame methods of determining the attitude of a nanosatellite are compared in this study. The methods selected for comparison are: Single Value Decomposition (SVD), q method, Quaternion ESTimator (QUEST), Fast Optimal Attitude Matrix (FOAM) − all solving optimally the Wahba’s problem, and the algebraic method using only two vector measurements. For proper comparison, two sensors are chosen for the vector observations on-board: magnetometer and Sun sensors. Covariance results obtained as a result of using those methods have a critical importance for a non-traditional attitude estimation approach; therefore, the variance calculations are also presented. The examined methods are compared with respect to their root mean square (RMS) error and variance results. Also, some recommendations are given.